Determining specific functional declines associated with progression from mild

 
   Lead Investigator:    Edmond Teng
   Institution      :    UCLA/Greater Los Angeles VA Healthcare System
   E-Mail           :    eteng@ucla.edu
   Proposal ID      :    204


   Publications:


1  Hsiao JJ, Lee GJ, Lu PH, Teng E
   Longitudinal declines in instrumental activities of daily living in stable and progressive mild cognitive impairment
   Abstract  Neurology,80:P07.154,2013,

   PUBLISHED



2  Hsiao JJ, Lu PH, Grill JD, Teng E
   Longitudinal declines in instrumental activities of daily living in stable and progressive mild cognitive impairment
   Journal Article  Dement Geriatr Cogn Disord,39:12-24,2015,PMC4312538

   PUBLISHED



3  Teng E, Tassniyom K, Lu PH
   Reduced quality-of-life ratings in mild cognitive impairment: analyses of subject and informant responses
   Journal Article  Am J Geriatr Psychiatry,20:1016-1025,2012,PMC3513348

   PUBLISHED





   Proposal Description:
   This project proposes to examine the relative longitudinal changes in cognitive, neuropsychiatric, and functional domains in the transition between mild cognitive impairment (MCI) and dementia.  MCI is considered an intermediate stage of cognitive decline that precedes dementia.  Typically, the key diagnostic distinction between MCI and dementia is the absence or presence of significant functional deficits.  Previous work from our group has examined cross-sectional differences between MCI and very mild AD subjects in the NACC UDS, and found that the AD subjects had significantly poorer performance on  instrumental activities of daily living (IADLs), both overall and in each specific category examined (Teng et al., Alzheimer Dis Assoc Disord 2010, 348-353). However, it remains uncertain which categories of IADLs are most sensitive to longitudinal decline and most closely related to diagnostic progression from MCI to dementia. This project aims to study subjects in the NACC database with a diagnosis of MCI at baseline and at least one follow-up assessment. We will calculate longitudinal change in IADLs using the Functional Activities Questionnaire (FAQ), and compare changes between MCI subjects that  progress to dementia with those that do not.  Since disease progression in MCI can be assessed in multiple ways, we will also determine the relative associations between diagnostic progression and longitudinal changes in functional, neuropsychological, and neuropsychiatric indices.  Finally, we will also include longitudinal analyses of subjects with normal cognition to control for any changes in these indices that may be attributed to normal cognitive aging.